There are at several other threads on this exact issue. That's been my experiene as well. Many launchers seem to be casualties of upgrading to 4.5. I personally have been in touch with CNN, ESPN, and Washington Post who all report no problems with their 4.5 Curve tests. I've uninstalled and re-installed many times, no joy. My son has an out-of-the-box 4.5 Verizon 8330 and those icons all work fine for him. No known fix here.
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I downloaded 4.5 myself and haven't had any problems with CNN. I had it there before the upgrade and it has been working fine afterwards. Probably not what you wanted to hear.
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I have ESPN quick launch and it also worked for me. I do have it set to one of my side keys though. I'm a bit of a sports addict. Hey the first step is admitting it.....right?! I'm also running OS 4.5. I havent had any issues really with anything I was running when I had OS 4.2, But I am still pretty new to this BLACKBERRY game.