I just had this problem when trying to install Blackberry Desktop Manager v4.3with Vista and Outlook 2007. The solution that worked for me was to remove Blackberry Desktop Manager v4.3 and install v4.2.2. I was then able to properly use Blackberry Desktop Manager on my computer and sync.
I have had a problem getting 4.3 to sync with outlook. Other message boards have said that many have downgraded to 4.2 (service pack 2) untill the bugs get worked out. My advice: remove the installation file and start over with 4.2.2.