I've had Desktop Manager 4.7 on my notebook for a few months. It worked fine for awhile, and all of a sudden it quit loading out of the blue, even after I hooked it up into my Blackberry. I recently just put in 5.0 beta thinking it would work, but no dice.
I see BlackBerry Device Manager, and it detects the USB connection with my PIN information.
I see RIMDevideManager.exe *32 and BbDevMgr.exe *32